Metabolic disorder affects gut health, disrupting homeostasis, glucose metabolism, and lipid metabolism.
This can lead to metabolic syndrome or related diseases, creating a vicious cycle.
Lipid metabolism includes biosynthesis and breakdown of fat such as fatty acid, triglycerides,
and cholesterol. Specialized lipoproteins help transport fat from the gut to the liver
(where most fat is processed) and between the liver and peripheral tissues.
Obesity is correlated to abnormal lipid metabolism, which can result in abnormal blood fat levels,
ectopic fat deposition, and metabolic related diseases such as nonalcoholic fatty liver disease
and atherosclerosis.。
1. HKSAR Gov Department of Health. (2020-2022). Population Healthy Survey
2. Yates KF, Sweat V, Lai YP, et al. Impact of Metabolic Syndrome on Cognition and Brain: A Selected Review of the Literature. Arterioscler Thromb Vasc Biol. 2012; 32(9): 2060–2067. https://doi.org/10.1161/ ATVBAHA.112.252759
3. Levin BE, Llabre MM, Dong C, et al. Modeling metabolic syndrome and its association with cognition: the Northern Manhattan study. J Int Neuropsychol Soc. 2014: 20(10): 951–60. https://doi.org/10.1017/ S1355617714000861
4. Mateusz Siedlinski, Carnevale, L., Xu, X., Carnevale, D., Evangelou, E., Caulfield, M. J., Maffia, P., Wardlaw, J. M., Samani, N. J., Tomaszewski, M., Lembo, G., Holmes, M. V., & Guzik, T. J. (2023). Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure. European Heart Journal, 44(23), 2114–2125. https://doi.org/10.1093/eurheartj/ehad101
5. Yaffe K, Vittinghoff E, Pletcher MJ, et al. Early adult to midlife cardiovascular risk factors and cognitive function. Circulation. 2014; 129(15): 1560–7. https://doi.org/10.1161/CIRCULATIONAHA.113.004798
6. *Cavalieri M, Ropele S, Petrovic K, et al. Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition. Diabetes Care. 2010; 33(12): 2489–2495. https://doi.org/10.2337/dc10-0851
7. #Exalto LG, van der Flier WM, van Boheemen CJ, et al. The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis. J Neurol Sci. 2015; 351(1–2): 18–23. https://doi. org/10.1016/j.jns.2015.02.004
8. The LKS Faculty of Medicine of the University of Hong Kong (HKUMed). (2024). High blood glucose weakens immunity against viral infections in type 2 diabetes patients