Scientific Studies

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Nu Skin demonstrates its tradition of innovation through its comprehensive product portfolio. Scientific research has been conducted on our products and this research has been published in scientific journals. See below to learn more about such scientific research and studies conducted on just a few of our products:

 

ageLOC

PUBLISHED ARTICLES

 

1.    Kern, D.G., Draelos, Z.D., Meadows, C., Morré, D.J., Morré, D.M. “Controlling Reactive Oxygen Species in Skin at Their Source to Reduce Skin Aging.” Rejuvenation Research. 2010 Apr-Jun;13(2-3):165-7.

 

2.    Gopaul, R., Knaggs, H., Langerveld, A. “Reducing Skin Stress Response with Willow Bark-Derived Salicin.” Cosmetic and Toiletries, (July, 2010): 32-36.

 

3.    Gopaul, R., Gibson, M., Knaggs, H., Holley, K., Lephart, J. “An Evaluation of the Effects of a Topical Product Containing Salicin on the Visible Signs of Human Skin Aging.” Journal of Cosmetic Dermatology, 9(3) 2010: 196-201.

 

4.    Knaggs, H. “Innovation in the Personal Care Industry.” Journal of Cosmetic Science 9(3) 2010; 260-263.

 

5.    Bartlett, M. “Nutritional and genetic strategies for longevity.” Anti-Aging Medical News. Winter 2010:36-40.

 

6.    Gopaul, R., Knaggs, H., Wickett, R. “A Review of Genomic Techniques in Cosmetic Testing.” Cosmetics & Toiletries. February 2011, pp. 112-117.

 

7.    Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J. “CordyMax Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” Proceeding of the 10th Symposium of Mycology Societies Across Taiwan Strait, Central China Agriculture University Publishing. 2011, pp 255-256.

 

8.    Li, C., Tan, N., Barger, J., Zhang, Y., Ferguson, S., Prolla, T., Zhu, J. “Combined use of ageLOC whole-gene expression profiling technology and mouse lifespan test in anti-aging herbal product study.” Proceeding of New TCM Products Innovation and Industrial Development Summit, Zhejiang University Publishing, Hangzhou. 27 Nov. 2011. (in press)

 

9.    Chang, A., Lingala, B., Chang, T., Kern, D., Wood, S., Toyoda, H., Knaggs, H. “An Exploratory Study to Determine the Association Between Assessed Facial Skin Aging and Plasma Isoprostane Levels in Middle-Aged Japanese Women.” Article first published online: 5 Dec. 2011 Dermatological Surgery. http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2011.02235.x/abstract.

 

10.  Gopaul, R., Kern, D.G., Knaggs, H.E., Lephart, J.F. (2012) Narcissus tazetta and Schizandra chinensis to Regulate ‘Youth Gene Clusters’—An In vitro Analysis. Cosmetics & Toiletries; 127, 6: 446-450.

11.  Gopaul, R., Knaggs, H.E., Lephart, E.D. (2012), Biochemical investigation and gene analysis of equol: A plant and soy-derived isoflavonoid with anti-aging and antioxidant properties with potential human skin applications. BioFactors. doi: 10.1002/biof.191

 

12.  Mastaloudis, A., Wood, S.M. Age-Related Changes in Cellular Protection, Purification and Inflammation-Related Gene Expression: Role of Dietary Phytochemicals. Annals of the New York Academy of Sciences. 1259(1):112-120; 2012.

 

13.  Mastaloudis, A. A Unique Nutritional Formulation to Promote Cellular Protection and Purification Via Induction of the Nrf2-mediated ARE/Phase II Detoxification Pathways. Second International Conference on Environmental Stressors in Biology and Medicine. Medimond s.l.r. Bologna, Italy. 11-17; 2012.

 

14.  Holley, K.C., Knaggs, H.E. Why Don’t I Look Younger? Euro Cosmetics 2013, 21: p. 32.

 

15.  Barger, J.L., Vann J.M., Mastaloudis, A., Wood, S.M., Bartlett, M.R., Prolla, T.A. Weindruch, R. Identification of transcriptional targets of healthspan in adipose tissue and modulation by resveratrol. Nutrition and Aging 2014;2:157-63.

 

16.  Meadows C, Morre DJ, Morre DM, Draelos ZD, and Kern D. Age-Related NADH Oxidase (arNOX)-Catalyzed Oxidative Damage to Skin Proteins. Archives of Dermatological Research, June 2014.  http://www.ncbi.nlm.nih.gov/pubmed/24906676.

 

17.  H Knaggs, S Wood, D Burke, J Lephart, J Namkoong.  (2016). The Contribution of Dietary Nutrients and Supplements to Skin Health. In Cosmetic Dermatology 2nd Edition (pp. 357-363). West Sussex, UK: John Wiley & Sons.

 

18.  Wood, S.M.; Mastaloudis, A.F.; Hester, S.N.; Gray, R.; Kern, D.; Namkoong, J. and Draelos, Z.D. Protective effects of a novel nutritional and phytonutrient blend on ultraviolet radiation-induced skin damage and inflammatory response through aging defense mechanisms. Journal of Cosmetic Dermatology. 16(4):491-499; 2017.

 

19.  Barger, J.L.; Vann, J.M.; Cray, N.L.; Pugh, T.D.; Mastaloudis, A.; Hester, S.N.; Wood, S.M.; Newton, M.A.; Weindruch, R. and Prolla, T.A. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. Aging Cell. 16(4):750-760; 2017. doi:10.1111/acel.12608

 

POSTERS

 

1.    “New Skin Benefits for White Willow Bark Extract.” The Society of Cosmetic Chemists Technology Showcase, December 2009. Gopaul, R., Langerveld, A., Lephart, J., Knaggs, H.

 

2.    “Antioxidation and lifespan-extension activities of CordyMax in oxidative stress and aging models #A177.” Oxidants and Antioxidants in Biology, Oxygen Club of California World Congress, March 17-20, 2010, Santa Barbara, CA. Zhu, J., Zhang, Y., Yang, J., Tan, N., Zhao, C., and Mastaloudis, A. (received DSM Research Award).

 

3.    “Age-Related Oxidase (arNOX) Implicated in Aging-Related Oxidative Damage to Skin Proteins,” Oxygen Club of California World Congress, March 2010, Santa Barbara, California. Morré, D.M., Morré, D.J., Meadows, C., Draelos, Z., and Kern, D.G.

 

4.    “CordyMax extends the lifespan in an aging model: a preliminary report, Abstract #A310.” Experimental Biology ’10, April 24-28, 2010 Anaheim, CA. Tan, N., Zhang, Y., Yang, J., Zhao, C., and Zhu, J.S.

 

5.    “Improvement of exercise metabolism and carotenoid antioxidant scores with CordyMax and LifePak in young Chinese elite athletes, Abstract #D356.” Experimental Biology ’10, April 24-28, 2010 Anaheim, CA. Duan, L., Zhao, L., Liang, C., Lu, L., Gao, L., Li, G., Zhu, J.S.

 

6.    “Maturational alteration of differential expressions of GC:AT-biased genotypes of Cordyceps sinensis fungi and Paecilomyces hepiali in Cordyceps sinensis, Abstract #B210.” Experimental Biology ’10, April 24-28, 2010 Anaheim, CA. Zhu, J.S., Gao, L., Yao, Y., Zhou, Y.

 

7.    “Antioxidation activities of CordyMax in an oxidative stress model: a mechanism of its anti-aging properties, Abstract #311.” Experimental Biology ’10, April 24-28, 2010 Anaheim, CA. Yang, J., Tan, N., Zhao, C., Zhang, Y., and Zhu, J.S.

 

8.    “Appearance in Japanese Women Correlates with Age-Related NADH Oxidase Levels and Blood Markers of Lipid Oxidation,” Society for Investigative Dermatology; J. Invest Dermatol 130. S. 6 (May 2010). Morré, D.J., Morré, D.M., Kern, D.G., Wood, S.M.

 

9.    “Regulating the Expression of Genes Associated with the Synthesis and Maintenance of Dermal Hyaluronan and Barrier Lipids Via Topical Treatment of Salicin—An In Vitro Analysis,” Society for Investigative Dermatology; J. Invest Dermatol 130. S. 84, May 2010. Gopaul, R., Knaggs, H.

 

10.  “Salicin Regulates the Expression of ‘Functional Youth Gene Clusters’ to Reflect a More Youthful Skin Profile,” International Federation of Societies of Cosmetic Chemists Annual Meeting, May 2010, Buenos Aires, Argentina. Gopaul, R., Langerveld, A., Knaggs, H., Lephart, J. 

 

11.  “Inhibition by Coenzyme Q10 of Age Related Oxidase (arNOX) Caused Oxidative Damage in Skin Proteins,” International Coenzyme Q Association Meeting, May 2010, Brussels, Belgium. Morré, D.M., Morré, D.J., Meadows, C., Draelos, Z., Kern, D.G.

 

12.  “Appearance in Japanese Women Correlates with the Presence of Inosotides and Lysolipids, Both Significant Inhibitors of Age-Related NADH Oxidase Levels,” 40th Annual European Society for Dermatological Research, June 2010. Morré, D.J., Morré, D.M., Kern, D.G., Wood, S.M., Toyoda, H., Knaggs, H.

 

13.  “Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4.” Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, Les Diblerets, Switzerland, August 21-27, 2010. Wood, S.M., Barger, J., Prolla, T.A., Weindruch, R., Mastaloudis, A., Ferguson, S.

 

14.  “Anti-Aging Effects of Superoxide Reduction in Skin by the Application of Specific Inhibitors of Age-Related NADH Oxidase (arNOX),” International Federation of Societies of Cosmetic Chemists, September 2010, Buenos Aires, Argentina. Kern, D.G., Meadows, C., Fuller, B.B., Knaggs, H., Morrѐ, D.M., Morrѐ, D.J.

 

15.  “Salicin Reduces the Expression of Genes Associated with Skin Inflammation—An In Vitro Analysis,” Society for Investigative Dermatology; J. Invest Dermatol 130. S. 85, September 2010. Gopaul, R., Knaggs, H.

 

16.  “Exploratory Study to Assess Association of Skin Aging with Plasma Isoprostane Levels in Healthy Middle-Aged Japanese Women.” The American Academy of Dermatology’s 69th Annual Meeting, February 2011, New Orleans, LA. Chang, A., Chang, T., Lingala, B., Kern, D., Wood, S., Toyoda, H., Knaggs, H.

 

17.  “A PCR-based screen to identify natural compounds with the ability to influence Nrf2-mediated transcriptional induction of detoxification/antioxidant genes.” Gordon Research Conference: Oxidative Stress & Disease. Emerging Research Areas in the Study of Oxidative Stress and Disease. March 13-18, 2011, Ventura, CA. Mastaloudis, A., Barger, J., Prolla, T., Weindruch, R., Ferguson, S., Wood, S.

 

18.  “Cordyceps sinensis Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” Progress in Nutrition 2011. The 5th International Symposium, “Promoting Good Health and Developing a Sustainable Environment,” Hong Kong, March 10-11, 2011. Zhu, J., Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M.

 

19.  “ageLOC Vitality improves exercise endurance, glucose metabolism and antioxidant capacity in an aging model.” Progress in Nutrition 2011. The 5th International Symposium, “Promoting Good Health and Developing a Sustainable Environment,” Hong Kong, March 10-11, 2011. Zhu, J., Yang, J., Dong, Y., Zhao, C., Wu, Z., Zhang, Y., Tan, N., Lu, J., Bartlett, M.

 

20.  “The lifespan-prolonging effect of Cordyceps sinensis Cs-4 in normal mice and its molecular mechanisms.” FASEB J 2011 25(1): 599.1. Experimental Biology 2011, Washington, DC, Apr. 10, 2011. Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J.

 

21.  “ageLOC Vitality improves endurance exercise, exercise glucose metabolism and antioxidant capacity in an aging model.” FASEB J 2011 25(1): 1049.2. Experimental Biology 2011, Washington, DC, Apr. 12, 2011. Yang, J., Dong, Y., Zhao, C., Wu, Z., Zhang, Y., Tan, N., Lu, J., Bartlett, M., Zhu, J.

 

22.  “Cordyceps sinensis Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” FASEB J 2011 25(1): 1090.13. Experimental 2011, Washington, DC, Apr. 13, 2011. Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J.

 

23.  “An ageLOC Vitality formula improves endurance exercise in aged mice and energy metabolism in muscle mitochondria.” FASEB J 2011 25(1): 1114.9. Experimental Biology 2011, Washington, DC, Apr. 13, 2011. Dong, Y., Lu, J., Yang, J., Zhao, C., Tan, N., Wu, Z., Zhang, Y., Gao, L., Bartlett, M., Zhu, J.

 

24.  “Association of skin aging severity with blood isoprostane levels in healthy middle-aged Japanese women.” Society for Investigative Dermatology (SID) May 2011, J. Invest Dermatol 131. S. 85 (2011). Chang, T., Lingala, B., Kern, D., Wood, S., Toyoda, H., Knaggs, H., Chang, A.

 

25.  “CordyMax Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” Proceeding of the 10th Symposium of Mycology Societies cross Taiwan Strait, Central China Agriculture University. 2011, pp 255-256. Oral presentation at: The 10th Symposium of Mycology Societies Cross Taiwan Strait, Wuhan, China, July 17, 2011. Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J.

 

26.  “A Multifactorial Approach to Addressing Body Appearance Aging.” European Society for Dermatological Research (ESDR) September 2011, J. Invest Dermatol 131. S. 54 (2011). Knaggs, H., Kern, D., Gopaul, R., Langerveld, A.

 

27.  “A Multifactorial Gene Expression Approach to Understanding Skin Aging.” J. Invest Dermatol 131. S. 57, September 2011. Knaggs, H., Kern, D., Bartlett, M., Wood, S., Mastaloudis, A., Ferguson, S., Langerveld, A.

 

28.  “A Systematic Approach to Evaluate and Rank Natural Ingredients Based on Their Ability to Oppose Age-Related Changes in Gene Expression.” Linus Pauling Institute Diet and Optimum Health Conference. Corvallis, OR. September 13-16, 2011. Wood, S., Mastaloudis, A., Barger, J., Prolla, T., Weindruch, R.

 

29.  “A unique blend of natural compounds with the ability to oppose age-related changes in gene expression related to dysregulation of removal of cellular debris, cellular detoxification, antioxidant protection and inflammatory balance.” Second International Conference on Environmental Stressors in Biology and Medicine. October 5-7, 2011, Centro Didattico, Policlinico Le Scotte Siena, Italy. Mastaloudis, A., Barger, J., Prolla, T., Weindruch, R., Bartlett, M., Wood, S.

 

30.  “Whole-gene transcriptional profiling to detect aging-associated mitochondria dysfunction and to develop an anti-aging product.” Proceeding of 2011 International Conference on Food Factors. Zhu, J.S., Dong, Y.Z., Barger, J.L., Lu, J.H., Tan, N.Z., Prolla, T.A., Weindruch, R., Bartlett, M. Invited Speaker at: The 2011 International Conference on Food Factors, Taiwan, November 20-23, 2011.

 

31.  “Combination of ageLOC biochip whole-gene expression profiling and mouse lifespan test in CM anti-aging study.” Proceeding of Summit of New TCM product Development and Industrial Development Strategy, China J Chinese Materia Medica Publishing. 2011. Li, C.L., Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J. Invited Speaker at: Summit of New TCM product Development and Industrial Development Strategy, Hangzhou, China, November 25-27, 2011.

 

32.  “Influencing the Expression of Genes Associated with Skin Inflammation by Combining Narcissus Tazetta Bulb Extract and Schizandra Chinensis Fruit Extract—an in vitro Analysis.” Society of Cosmetic Chemists Annual Scientific Seminar, New York, NY, December 2011. Gopaul, R., Knaggs, H., Kern, D.

 

33.  “So Why Don’t I Look Younger?” International Federation of Societies of Cosmetic Chemists, Bangkok, Thailand, December 14-15, 2011. Kern, D., Chang, A., Wood, S., Gopaul, R., Lephart, J., Knaggs, H.

 

34.  Chang, A.L.S., Spitale, R., Torre, E., Lingala, B., Chang, H.Y., Kern, D.G., Wood, S.M., Knaggs, H. E. Transcriptional profiling to identify genes controlling human skin aging presented at the 70th Annual Meeting of the American Academy of Dermatology in San Diego on March 16-20, 2012. J Am Acad Dermatol 66(4), AB32 (2012).

 

35.  Gopaul, R., Kern, D.G., Knaggs, H.E. L. Digitata influences expression of genes related to vasculature and may therefore be beneficial for improving the appearance of cellulite presented at Society for Investigative Dermatology, May 9-12, 2012. Supplement to the Journal of Investigative Dermatology 132(1), S65 (2012).                     

 

36.  Gopaul, R., Kern, D.G., Knaggs, H.E. L. Digitata influences gene expression relating to adipogenesis and lipolysis and thus may be used as an active ingredient for addressing cellulite presented at Society for Investigative Dermatology, May 9-12, 2012. Supplement to the Journal of Investigative Dermatology 132(1), S65 (2012).         

 

37.  Mastaloudis, A., Barger, J.L., Prolla, T.A., Weindruch, R., Wood, S.M. A unique blend of natural compounds opposes age-related changes in gene expression related to dysregulation of cellular detoxification and antioxidant protection. Society for Free Radical Research International, London, England. September 6-9, 2012. 

 

38.  Kern, D.G., Draelos, Z.D., Gopaul, R., Lephart, J., Knaggs, H.E. Microcurrent Skin Treatment Outperforms a Standard Retinol Topical in the Treatment of Cellulite Skin Topography presented at the 42nd Annual Meeting of the European Society for Dermatological Research in Venice, Italy on September 19-22, 2012.

 

39.  Gopaul, R., Kern, D.G., Knaggs, H.E., Lephart, J.F. Regulating the Expression of Genes Associated with the Protection and Maintenance of Skin Structure via Topical Treatment of Narcisscus Tazetta Bulb Extract and Schizandra Chinensis Fruit Extract- an In vitro Analysis presented at the 42nd Annual Meeting of the European Society for Dermatological Research in Venice, Italy on September 19-22, 2012.

 

40.  Gopaul, R., Knaggs, H.E., Kern, D.G., Lephart, J.F. Targeting Genes Related to Skin Firmness—an in-vitro Approach presented at the Annual Society of Cosmetic Chemists Meeting in New York, NY on December 6-7, 2012.

 

41.  Wood, S.M., Poole, S., Burke, D., Bartlett, M., Mastaloudis, A. Weight management program, including a blend of natural compounds, facilitates weight loss in overweight men and women: a pilot study. Experimental Biology, Boston MA. FASEB J April 9, 2013 27:851.14.

 

42.  Wood, S.M., Poole, S., Bartlett, M., Mastaloudis, A., Burke, D. Effects of a novel dietary supplement on physical and mental function in middle-aged adults: a double-blind, randomized, placebo-controlled trial. Experimental Biology, Boston, MA. FASEB J April 9, 2013 27:1076.8.

 

43.  N-Z. Tan, J-Y. Yang, G. Yang, J-S. Zhu. ageLOC vitality improves memory and learning ability in memory impairment models. Experimental Biology, Boston MA. FASEB J April 9, 2013 27: 661.4.

 

44.  L. Gao, Y-S. Yao, Z. Wu, J-S. Zhu. Changes in RAPD molecular marker polymorphism during Cordyceps sinensis maturation. Experimental Biology, Boston MA. FASEB J April 9, 2013 27: 1079.13.

 

45.  L. Gao, Y. Zhang, J-H. Lu, N-Z. Tan, J-S Zhu. Cs-5 modulating immune response in a normal adult model. Experimental Biology, Boston MA. FASEB J April 9, 2013 27: 866.1.

 

46.  J-Y. Yang, Y. Zhang, Y-Z. dong, N-Z. Tan, J-H. Lu and J-S. Zhu. Cordyceps sinensis Cs-5 enhances sexual functions in normal and impotent models. Experimental Biology, Boston MA. FASEB J April 9, 2013 27: 1167.8.

 

47.  Kern, D.G., Stephens, T.J., Knaggs, H.E. An instrument-applied topical product affects skin microvasculature and may therefore be beneficial for improving the appearance of cellulite presented at the International Investigative Dermatology meeting on May 8-11, 2013 in Edinburgh, Scotland.

 

48.  Kern, D.G., Knaggs, H.E., Gopaul, R., Bevis, D.J., Kilkuskie, R.E., Lehigh, E.A., Langerveld, A.J., Pfund, W.P. An in vitro method for identifying agents with lipofilling-like activity: Parallel Assessment of lipid accumulation, toxicity and gene expression presented at the International Investigative Dermatology meeting on May 8-11, 2013 in Edinburgh, Scotland.

 

49.  Gopaul, R., Kern, D.G., Namkoong, J., Knaggs, H. Targeting Genes Related to Skin Firmness—an In Vitro Approach presented at Society of Cosmetics Chemist in December 12-13, 2013 in New York, New York.

 

50.  A.S. Chang, R Spitale, R Li, E Torre, D.G. Kern, H.E. Knaggs. Identification of Gene Expression Signatures in Older Women with Youthful Appearing Skin presented at Society for Investigative Dermatology (SID) in Albuquerque, NM on May 7-10, 2014.

 

51.  D.G. Kern, J. Namkoong, H.E. Knaggs, R. Gopaul, D.J. Bevis, R.E. Kilkuskie, E.A. Lehigh, A.J. Langerveld, W.P. Pfund. An in vitro Method for Identifying Agents with Lipofilling-like Activity: Assessment of Lipid Accumulation, Tissue Source, Age, and Gene Expression presented at Society for Investigative Dermatology (SID) in Albuquerque, NM on May 7-10, 2014.

 

52.  Jin Namkoong. A Special Lunch Presentation: Nu Skin Company Highlighting Recent Scientific Posters presented at Happi’s Anti-Aging Conference, September 17, 2014.

 

53.  Namkoong, J, Cook, B, Larsen, K, Zhou, H, Landreth, B, Lehigh, E, Langerveld, A, Stevenson, D, Knaggs, H. Assessment of Jasmine essential oils on skin equivalents  presented at 12th Biannual Conference of the Asian Societies of Cosmetic Chemists on April 28-30, 2015 in Cairns, Australia.

 

54.  Namkoong, J, Kern, D, Gopaul, R, Lehigh, E, Langerveld, A, Knaggs, H. Epigenetic modulation of skin equivalents by cosmetic ingredients presented at the Society for Investigative Dermatology on May 6-9, 2015 in Atlanta, GA.

 

55.  Xu, J, Spitale, R, Flynn, R, Torre, E, Li, Rui, Raber, I, Kern, D, Knaggs, H, Chang, H, Chang, A. Hyaluronan synthase 2 antisense transcript level associates with human skin youthfulness as identified by transcriptome sequencing presented at the Society for Investigative Dermatology on May 6-9, 2015 in Atlanta, GA.

 

56.  Stephens, B, Namkoong, J, Kern, D, Gopaul, R, Knaggs, H. Gene and epigenetic expression patterns of same-genome skin equivalent constructs exposed to single and combination of cosmetic ingredients presented at 23rd World Congress of Dermatology June 8-13, 2015. Vancouver, Canada.

 

57.  Namkoong, J, Cook, B, Stevenson, D, Kern, D, Knaggs, H. A design strategy for comprehensive quality control of botanicals: a case study with essential oils presented at the International Federation of Societies of Cosmetic Chemists in Zurich Switzerland on September 22-23, 2015.

 

58.  D Kern, J Namkoong, R Best, I Ansell, A Norman, O Godbold, H Innes, K Fuller, and H Knaggs. A Key Strategy to Support the Evolution of Personalized Skin Care. Presented at the International Federation of Societies of Cosmetic Chemists in Zurich Switzerland on September 22-23, 2015.

 

59.  Wood, S.M.; Gray, R.; Kern, D.; Hester, S.N.; Mastaloudis, A.; Namkoong, J.; and Draelos, Z.D. Novel Nutritional Formula Protects Against Cellular Damage. FASEB Journal 30:692.5; April 2016.

 

60.  Choy, Y.Y.; Hester, S.N.; Mastaloudis, A.; Wood, S.M.; Gray, R.; O’Donnell, R.P.; Barger, J.L.; Quifer-Rada, P.; Lamuela-Raventós, R.M. and Waterhouse, A.L. Nutritional Polyphenol Metabolites’ Kinetics in Plasma, Urine, and Saliva Following Consumption by Normal, Healthy, Subjects. FASEB Journal 30:690.2; April 2016.

 

61.  Cremonini, E.; Anderson, M.; Waterhouse, A.L.; Mastaloudis, A.; Wood, S.M.; Hester, S.N.; Verstraeten, S.; Fraga, C.G. and Oteiza, P.I. Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Proceedings of the Oxygen Club of California 2016 World Congress; University of California at Davis, Davis, CA. A80; May 4-6, 2016.

 

62.  Mastaloudis, A.; Serna, E.; Wood, S.M.; Hester, S.N.; Weindruch, R.; Prolla T.A. and Vina, J. A Novel Nutrient Blend Mimics Calorie Restriction Transcriptional Patterns in Brain of Mice. Proceedings of the Oxygen Club of California 2016 World Congress; University of California at Davis, Davis, CA. A105; May 4-6, 2016.

 

63.  J. Namkoong, B. Cook, D. Kern, H.E. Knaggs. Topical Treatments Improved Periorbital Aging. Journal of Investigative Dermatology, May 2016 Volume 136, Issue 5, Supplement 1, Page S47. Poster presented at Society for Investigative Dermatology on May 11-14, 2016 in Scottsdale, AZ.

 

64.  S. Wood, R. Gray, S. Hester, A. Mastaloudis, D. Kern, J. Namkoong, Z.D. Draelos. Nutritional Supplementation Improves Skin Health, May 2016 Volume 136, Issue 5, Supplement 1, Page S103. Poster presented at Society for Investigative Dermatology on May 11-14, 2016 in Scottsdale, AZ.

 

65.  Dale Kern, Kara C. Holley, Remona Gopaul, Melanie Riggs, Jin Namkoong, Helen E. Knaggs. Instrumental Enhancement of Topical Skin Care Product Performance. Poster presented at International Federation of Societies of Cosmetic Chemists on October 30-Novemeber 2, 2016 In Orlando, FL.

 

66.   DG Kern, ZD Draelos, J Namkoong, M Riggs, and HE Knaggs. A Unique Sensitive Skin Cleansing Technology. Poster presented at the American Academy of Dermatology annual meeting on March 3-7 2017 in Orlando, FL.

 

67.  S. Jones, D. A. Hart, A. Blythe, J. Ronsky, J. Namkoong, and D. Kern. The influence of a novel mechanical loading regimen on the molecular response of human facial skin cells. Poster presented at the Society for Investigative Dermatology meeting on April 26-29 in Portland, OR.

 

68.  Jin Namkoong, Dale G. Kern, and Helen E. Knaggs. Preliminary Evaluation of Gene Expression Changes from Tape Strippings. Poster presented at the Society for Investigative Dermatology meeting on April 26-29 in Portland, OR.

 

69.  Subramaniam, P.; Mastaloudis, A.; Wood, S.M.; Hester, S.N.; McGlade, E.C.; Renshaw, P.F. and Yurgelun-Todd, D.A. Alterations in Brain Connectivity Following Supplementation with a Putative Caloric Restriction Mimetic Blend of Nutrients and Phytochemicals. American Society of Clinical Psychopharmacology Annual Meeting, Miami, FL, May 29 - June 2, 2017.

 

70.  Mastaloudis, A.; Serna, E.; Wood, S.M.; Hester, S.N.; Weindruch, R.; Prolla T.A. and Vina, J. A Novel Nutrient Blend Mimics Calorie Restriction Transcriptomics Differentially in Multiple Tissues of Mice. Proceedings of the Oxygen Club of California 2016 World Congress; Berlin, Germany. A235; June 21-23, 2017.

 

71.  Mastaloudis, A.; Serna, E.; Wood, S.M.; Hester, S.N.; Weindruch, R.; Prolla T.A. and Vina, J. A Long-term supplementation with a novel nutrient blend mimics calorie restriction transcriptomics in multiple tissues of old mice. Linus Pauling Institute Diet and Optimum Health Conference; Corvallis, Oregon. A33; September 13-16, 2017.

 

72.   DG Kern, J Namkoong, M Riggs, B Cook, ZD Draelos, HE Knaggs.  A Novel Device for Skin Type-Based Treatment While Cleansing. Poster presented at the 47th Annual European Society of Dermatological Research on September 27-30, 2017 in Salzburg, Austria.

73.  DG kern, J Namkoong, M Riggs, HE Knaggs. Digital image analysis of skin improvement following use of a novel treatment cleansing technology. Poster presented at International Federation of Societies of Cosmetic Chemistry in Seoul, Korea on October 23-25, 2017.

 

 

ORAL PRESENTATIONS

 

1.    “Resveratrol mimics caloric restriction and retards aging in the heart.” Oxidants and antioxidants in biology, Oxygen Club of California World Congress, Santa Barbara, CA, March 17-20, 2010. Prolla, T.

 

2.    “Aging and Genes—the Link with Skin.” New York Society of Cosmetic Chemists Meeting, March 2010, Knaggs, H.

 

3.    “Transcriptional biomarkers of age and their modulation by dietary intervention.” Invited Speaker: CoLONGY, The 1st International Congress on Controversies in Longevity, Health and Aging. Barcelona, Spain, June 24-27, 2010. Barger, J., Wood, S.M., Weindruch, R., Prolla, T.

 

4.    “Mitochondria and Aging.” Japan Symposium. Mechanisms of Ageing and Development, September 2010;13:449-450;480-486. Prolla, T.

 

5.    “A nutritional strategy to oppose the genetic expression of aging and loss of vitality.” 1st World Congress on Targeting Mitochondria, Strategies, Innovation and Clinical Applications, Berlin, Germany, November 18-19, 2010. Wood, S.M., Ferguson, S.B., Barger, J.L., Prolla, T.A., Weindruch, R., Bartlett, M.

 

6.    “Targeting age-related gene expression improves mental and physical vitality.” 1st World Congress on Targeting Mitochondria, Strategies, Innovation and Clinical Applications, Berlin, Germany, November 18-19, 2010. Ferguson, S.B., Tan, N., Dong, Y., Lu, J., Fisk, N.A., Wood, S.M., Zhu, J., Bartlett, M.

 

7.    “Genes and Aging: Links to Skin,” In-Cosmetics Asia; Bangkok, Thailand, November 2010. Knaggs, H.

 

8.    “Why Do People Look Younger for Their Age,” Asian Cosmetic Chemistry Society, Singapore, China, November 2010. Knaggs, H.

 

9.    “A Review of Current Genomic Techniques Used in Gene Expression Profiling of the Skin,” Society of Cosmetic Chemists Annual Meeting; New York, New York, December 2010. Gopaul, R.

 

10.  “Transcriptional biomarkers of calorie restriction and their modulation by dietary interventions.” Invited Speaker: Free Radicals, Nutrition and Aging: From Fundamental Aspects to Clinical Applications. Paris, France, June 15-17, 2011. Barger, J.

 

11.  “CordyMax Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” The 10th Symposium of Mycology Societies Across Taiwan Strait, Wuhan, China, July 17, 2011. Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J.

 

12.  “Transcriptional biomarkers of calorie restriction in adipose tissue and modulation by dietary interventions.” Invited Speaker: Linus Pauling Institute Diet and Optimum Health Conference. Corvallis, OR, September 13-16, 2011. Barger, J.

 

13.  “A unique nutritional formulation to promote cellular protection and purification via induction of the Nrf2-mediated ARE/Phase II detoxification pathways.” Invited Speaker: Second International Conference on Environmental Stressors in Biology and Medicine. Centro Didattico, Policlinico Le Scotte Siena, Italy. October 5-7, 2011. Mastaloudis, A.

 

14.  “Restructuring of the ECM in Human Skin by Equol: A Plant and Soy-Derived Isoflavonoid.” Gene Expression and Protein Evidence presented at the 4th International Conference and Exhibition for Nutraceuticals and Functional Foods, Sapporo, Japan, November 2011. Gopaul, R., Knaggs, H., Lephart, E.

 

15.  “Whole-gene transcriptional profiling to detect aging-associated mitochondria dysfunction and to develop an anti-aging product.” Invited Speaker: The 2011 International Conference on Food Factors, Taiwan, November 20-23, 2011. Zhu, J., Dong, Y., Barger, J., Lu, J., Tan, N., Prolla, T., Weindruch, R., Bartlett, M.

 

16.  “Combination of ageLOC biochip whole-gene expression profiling and mouse lifespan test in CM anti-aging study.” Invited Speaker: Summit of New TCM product Development and Industrial Development Strategy, Hangzhou, China, November 25-27, 2011. Li, C., Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J.

 

17.  Knaggs, H.E. Why Don’t I Look Younger? Presented at HBA Global Expo in New York City, NY; June 2012.

 

18.  “Experimental proof of lifespan extension property and the molecular mechanisms of anti-aging herbs Cordyceps sinensis and Ganoderma lucidum.” Invited Speaker: TWGHs Sophia Wang Eddie Wang Integrated Chinese and Western Medicine Symposium 2012/13, Hong Kong, China, March 7, 2013. Zhu, Josh.

 

19.  “Amplicon density-weighted algorithms analyze high dissimilarity and dynamic alterations of RAPD molecular marker polymorphisms in the integrated microecology Cordyceps sinensis with multiple fungi.” The 11th Symposium of Mycol Societies cross Taiwan Strait, Beijing, China, May 17-19 2013. Zhu, Josh.

 

20.  Barger, J. “Transcriptional biomarkers of aging and modulation by dietary interventions” International Association of Gerontology and Geriatrics: Seoul, South Korea, June 25, 2013.

 

21.  Barger, J. "Conserved pathways to longevity and modulation by resveratrol"
Wine Health 2013: Sydney, Australia, July 19, 2013.

 

22.  “Anti-oxidation and lifespan extension activities of Cordyceps sinensis Cs-4.” The 7th International Medicinal Mushroom Conference, Beijing, China, August 26-29, 2013. Zhu, J., Wu, Z.

 

23.  “Anti-oxidation and lifespan extension activities of Cordyceps sinensis Cs-4 and the anti-aging molecular mechanisms.” Biennial Meeting of Society for Free Radical Research-Asia, Taiwan, October 16-19, 2013. Zhu, J., Tan, L.

 

24.  Barger, J. “Resveratrol mimics health span effects of calorie restriction in white adipose tissue"
6th International Conference on Polyphenols and Health: Buenos Aires, Argentina, October 19, 2013.

 

25.  Barger, J. "Nutrigenomic approaches to slowing the aging process” Vision 2020 Seminar series, University of Zurich, November 21, 2013.

 

26.  “The Big Debate: Where Industry Professionals See the Future of the Industry Going.” Cosmetics Vision March 5-7, 2014 in Cannes, France, King, Will, Pessikoff, Robert, and Knaggs, Helen.

 

27.  “Brand Case Study: Exploring the Challenges and Opportunities in Doing Business in Global Markets.” HBA June 12, 2014 in New York, NY. Knaggs, Helen.

 

28.  “Identification of Novel Mechanisms behind Skin Aging.” Happi’s Anti-Aging Conference, September 16, 2014 in New Brunswick, NJ. Knaggs, Helen.

 

29.  “Exploring the Challenges and Opportunities in Doing Business in Global Markets.” Happi’s Anti-Aging Conference, September 17, 2014 in New Brunswick, NJ. Knaggs, Helen.

 

30.  Knaggs, Helen. Exploring mechanisms of antiaging-does one size fit all? Platform presentation at the 12th Biannual Conference of the Asian Societies of Cosmetic Chemists on April 28-30, 2015 in Cairns, Australia.

 

31.  H Knaggs, B Cook. Essential Oil Presentation, Q&A, and round table discussion. SkinCare Ingredients 2015. Online Wednesday June 24.

 

32.  “An approach for customizing skin care regimens.” Cosmetics & Personal Care Tech Asia 2016, May 26-27th, 2016 in Shanghai, China. Knaggs, Helen.

 

33.  “Essential Oils in Personal Care: A volatile mix of challenge and opportunity.” In-Cosmetics North America, September 7, 2016 in New York, NY. Cook, Brian.

 

34.  “An approach for customizing skin care.” European Dermocosmetologic Days, January 30th and 31st in Lyon, France. Knaggs, Helen.

 

35.  DG Kern. “Beneficial Skin Movement: In Vitro to In Vivo” presented at Cosmetic R&D Technology Cooperation in Shanghai, CN on May 8-9, 2017.

 

36.  H Knaggs. “Future of formulations in cosmetics Efficacy – to formulate or to engineer?” presented at the 3rd Future of Formulations In Cosmetics in Barcelona, Spain on May 17-18, 2017.

 

 

AWARDS

 

1.    Angela Mastaloudis, Ph.D. Senior Scientist, Received the DSM Nutraceutical Research Award 2010.

 

2.    Nu Skin Awarded Utah Innovation Award for ageLOC Vitality: Natural Products category, 2011.

 

3.    2012 Golden Bridge Awards—Dr. Joe Chang Most Innovative Person of the Year.

 

4.    Nu Skin received Utah Innovation Honorable Mention Award for ageLOC R2: Consumer Products category, 2012.

 

5.    Helen Knaggs named Gold Winner for Most Innovative Woman of the Year by Women in Business and the Professions, 2015.

 

6.    Women Tech Council named Helen Knaggs a Finalist for Innovator of the Year 2015.

 

7.    Nu Skin won the 2015 Good Design Award by Chicago Athenaeum for ageLOC Me.

 

8.    ageLOC Me won the 2016 Techie Award for the Most Innovative Retail Product.

 

9.    ageLOC Me received a 2016 platinum A’ Design Award in the Beauty, Personal Care, and Products Design category for innovation, technology, design, and creativity.

 

10.  Nu Skin Scandinavia won two awards in the 2016 Biotechnology awards, which showcase the very best discoveries from companies working within the anti-aging industry.

 

11.  ageLOC Me received the Big Innovation award as a 2016 Top Innovation from a panel of industry experts.

 

12.  ageLOC Me won the 2016 Best Beauty Supplement/Device/Skin Care Innovation category award.

 

13.  ageLOC Me was awarded the Edison Award – Silver, 2017.

 

14.  ageLOC Me was awarded the Best in Biz Award – Silver, 2017.

 

15.  ageLOC Me won the Bronze Stevie for New Product or Service Introduction of the Year, 2017.

 

16.  ageLOC LumiSpa received the Golden Bridge Award – Silver, 2017.

 

17.  ageLOC Youth received Her World Beauty Awards for the anti-aging supplement category, 2017.

 

18.  ageLOC Me received Marie Claire's Futuristic Top 20 award, 2017.

 

19.  ageLOC Tru Face Essence Ultra Duet won The Pure Beauty Awards (UK): Best New Premium Skin Care Product, 2017.

 

20.  ageLOC Tru Face Essence Ultra Duet won The Beauty Awards with OK Magazine! (UK): Best New Premium Skin Care Product, 2017.

 

21.  Nu Skin was awarded in Direct Selling Australia for Product Innovation, 2017.

 

 

Tegreen 97

Tegreen 97 is a proprietary, highly concentrated extract of polyphenols, a large percentage of which are antioxidant catechins found naturally in green tea that promote long-term cellular health. *

 

Gradecka-Meesters D, Palus J, Prochazka G, Segerbäck D, Dziubałtowska E, Kotova N, Jenssen D, Arkusz J, Lundin C, Vikström E, Rydzyński K, Nilsson R, Stępnik M. Food Chem Toxicol. 2011 Aug;49(8):1674-83. http://www.ncbi.nlm.nih.gov/pubmed/21376772

 

Thyagarajan A, Zhu J, Sliva D. International Journal of Oncology. 2007; 30(4):963-9. https://www.spandidos-publications.com/ijo/30/4/963/abstract

 

Sartippour MR, Pietras R, Marquez-Garban DC, Chen HW, Heber D, Henning SM, Sartippour G, Zhang L, Lu M, Weinberg O, Rao JY, Brooks MN. Carcinogenesis. 2006 Dec;27(12):2424-33. http://carcin.oxfordjournals.org/content/27/12/2424.full.pdf+html

 

Lu QY, Jin YS, Pantuck A, Zhang ZF, Heber D, Belldegrun A, Brooks M, Figlin R, Rao J. Clin Cancer Res. 2005 Feb 15;11(4):1675-83. http://clincancerres.aacrjournals.org/content/clincanres/11/4/1675.full.pdf

 

Chui A, Wingfield ER, Kern K, Kohler S, Kimball AB. A double-blinded, placebo-controlled trial to determine the role of a combination regimen of systemic and topical green tea in UV protection and the improvement of skin appearance. 2005. http://cat.inist.fr/?aModele=afficheN&cpsidt=16984978

 

Henning SM, Niu Y, Lee NH, Thames GD, Minutti RR, Wang H, Go VL, Heber D. Am J Clin Nutr. 2004 Dec;80(6):1558-64. http://ajcn.nutrition.org/content/80/6/1558.full.pdf+html

 

Morré DJ, Morré DM, Sun H, Cooper R, Chang J, Janle EM. Pharmacology &Toxicology. 2003 May;92(5):234-41. http://www.ncbi.nlm.nih.gov/pubmed/12753411

 

Yu H, Zhu Z, Yin W, Zhu JS. Presented at Annual Meeting of Experimental Biology (FASEB), April 2003, San Diego, CA. http://px2.com.tw/poster/No3.TG%20EB2003%20poster.pdf

 

Sartippour MR, Heber D, Zhang L, Beatty P, Elashoff D, Elashoff R, Go VL, Brooks MN. Int J Oncol. 2002 Sep;21(3):487-91. http://www.ncbi.nlm.nih.gov/pubmed/12168090

 

Sartippour MR, Shao ZM, Heber D, Beatty P, Zhang L, Liu C, Ellis L, Liu W, Go VL, Brooks MN. J Nutr. 2002; 132(8):2307-11. http://jn.nutrition.org/content/132/8/2307.full.pdf+html

 

Sartippour MR, Heber D, Shao ZM, Lui C, Lu QY, Go VL, Nguyen M. J. Nutr. 131: pg 3141, 2001. http://jn.nutrition.org/content/131/11/3133S.full.pdf+html

 

Sartippour MR, Heber D, Ma J, Lu Q, Go VL, Nguyen M. Nutrition and Cancer, 2001; 40(2), 149–156. http://www.ncbi.nlm.nih.gov/pubmed/11962250

 

Pillai SP, Mitscher LA, Menon SR, Pillai CA, Shankel DM. Journal of Environmental Pathology, Toxicology, and Oncology. 1999;18(3):147-58. http://www.ncbi.nlm.nih.gov/pubmed/15281227

 

CordyMax Cs-4

CordyMax Cs-4 is a proprietary, standardized extract of the Cordyceps Sinensis mushroom that promotes stamina and vitality while reducing fatigue. *

 

Nicodemus KJ, Hagan RD, Zhu JS, Baker C. Supplementation with Cordyceps Cs-4 fermentation product promotes fat metabolism during prolonged exercise.

Medicine and Science in Sports and Exercise. 2001; 33(5):S164. http://journals.lww.com/acsm-msse/pages/toc.aspx?year=2001&issue=05001

 

Zhu JS, Nicodemus KJ, Hagan RD, and Baker C. CordyMax Cs-4 improves cardiovascular and metabolic capacity during exercise in highly-fit athletes.

FASEB Journal 16(4): A628; 2002. [no online abstract available]

 

Zhu JS, Yin WT, Nicodemus KJ. CordyMax Cs-4 improves glucose metabolism. FASEB Journal 15; 2001. http://www.ncbi.nlm.nih.gov/pubmed/12165188

 

Xiao Y, Huang XZ, Chen G, Wang MB, Zhu JS, Cooper CB,. Increased aerobic capacity in healthy elderly humans given a fermentation product of Cordyceps Cs-4. Medicine and Science in Sports and Exercise1999; 31(5) Suppl, S174. http://journals.lww.com/acsm-msse/pages/toc.aspx?year=1999&issue=05001

 

Talbott SM, Zhu JS, Rippe JM,. CordyMax Cs-4 enhances endurance in sedentary individuals. Am J Clinic Nutri, 2002; 75(2) Supplement, 401S. http://www.ajcn.org/cgi/reprint/75/2/339S.pdf

 

Zhu JS, Rippe JM,. CordyMax enhances aerobic capability, endurance performance, and exercise metabolism in healthy, mid-age to elderly sedentary humans. FASEB J. 2004; 18(5): A931. [no online abstract available]

 

Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010

May;16(5):585-90. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110835/

 

Zhu JS, Pei Y, Xu Z, Wang B, Rippe JM. CordyMax reduces serum oxidized LDL-cholesterol and increases HDL-cholesterol in humans with reduced HDL cholesterol. Circulation (J Am. Heart Asso.) 2003; 108(17), Abstract# 3524. [no online abstract available]

 

Dai GW, Bao TT, Xu CF, Cooper R, Zhu JS. CordyMax Cs-4 improves steadystate bio-energy status in mouse liver. J. Altern. Compli. Med. 2001;7(3):231-240. http://www.ncbi.nlm.nih.gov/pubmed/11439844

 

Dai GW, Bao TT, Xu CF, Cooper R, Zhu JS, and Cooper CB. Enhanced hepatic energy state in mice after administration of a fermentation product of Cordyceps Cs-4. Medicine and Science in Sports and Exercise 1999; 31:S120 (Abstract). http://journals.lww.com/acsm-msse/pages/toc.aspx?year=1999&issue=05001

 

Balon TW, Jasman AP, Zhu JS. A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats. J Altern Comp Med 2002; 8(3):315-23. http://www.ncbi.nlm.nih.gov/pubmed/12165189

 

Zhao CS, Yin WT, Wang JY, Zhang Y, Yu H, Cooper R, Smidt C, Zhu JS. CordyMax Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats. J Altern Complement Med 2002; 8(3):309-14. http://www.ncbi.nlm.nih.gov/pubmed/12165188

 

Tan NZ, Zhang Y, Yang JY, Zhao C, Zhu JS. CordyMax extends the lifespan in an aging model: A preliminary report. FASEB J. 2010; 24: (Meeting Abstract Supplement) 947.1. http://www.fasebj.org/content/24/1_Supplement/947.1.short

 

Yang JY, Tan NZ, Zhao C, Zhang Y, Zhu JS. Anti-oxidation activities of CordyMax in an oxidative stress model: A mechanism of its anti-aging property. FASEB J. 2010; 24: (Meeting Abstract Supplement) 947.2. http://www.fasebj.org/content/24/1_Supplement/947.2

 

Duan L, Zhao L, Liang C, Lu J, Gao L, Li G, Zhu JS. Improvement of exercise metabolism and carotenoids antioxidant scores with CordyMax and LifePak in young Chinese elite athletes. FASEB J. 2010; 24: (Meeting Abstract Supplement) 805.4. http://www.fasebj.org/content/24/1_Supplement/805.4.short?related-urls=yes&legid=fasebj;24/1_Supplement/805.4

               

Tan NZ, Barger JL, Zhang Y, Ferguson SB, Wu ZM, Prolla TA, Bartlett M, Zhu JS. Cordyceps sinensis Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice. FASEB J. 2011;25:1090.13. http://www.fasebj.org/content/25/1_Supplement/1090.13?related-urls=yes&legid=fasebj;25/1_Supplement/1090.13

 

Tan NZ, Barger JL, Zhang Y, Ferguson SB, Wu ZM, Prolla TA, Bartlett M, Zhu JS. The lifespan-extending effect of Cordyceps sinensisCs-4 in normal mice and its molecular mechanisms. FASEB J.2011; 25:599.1. http://www.fasebj.org/content/25/1_Supplement/599.1.short?related-urls=yes&legid=fasebj;25/1_Supplement/599.1

 

ReishiMax GLp

ReishiMax GLp is a standardized Reishi mushroom extract that incorporates cracked spores, a proprietary technology that releases Reishi’s active ingredients, providing unique immune system activity not found in other Reishi products. *

 

Yang J, Wu Z, Yao Y, Zhang Y, Zhao C, Dong Y, Tan NZ, Zhu JS. ReishiMax improves antioxidant capacity in an oxidative stress model and extends lifespan in a natural aging model. FASEB J. April 2012 (26): 373.2. http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/373.2

 

Wu Z, Zhang Y, Tan NZ, Zhao C, Zhu JS. ReishiMax extends the lifespan of mice: A preliminary report  FASEB J, 2011 25:Abstract #601.2. http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/601.2

 

Tan NZ1, Zhang Y1, Yang J1, Zhao C1, Zhu JS2,3. ReishiMax extends the lifespan in an aging model: A preliminary report. FASEB J. April 2010 (24): Abstract #738.5. http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/738.5

 

Thyagarajan-Sahu A, Lane B, Sliva D. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK. BMC Complement Altern Med. 2011 Sep 19;11:74. http://www.biomedcentral.com/content/pdf/1472-6882-11-74.pdf

 

Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, Jiang J, Sliva D. Nutr Cancer. 2010;62(5):630-40. http://www.ncbi.nlm.nih.gov/pubmed/20574924

 

Adamec J, Jannasch A, Dudhgaonkar S, Jedinak A, Sedlak M, Sliva D. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds. J Sep Sci. 2009 Dec;32(23-24):4052-8. http://www.ncbi.nlm.nih.gov/pubmed/19937965

 

Dudhgaonkar S, Thyagarajan A, Sliva D. Int Immunopharmacol. 2009 Oct;9(11):1272-80. http://www.ncbi.nlm.nih.gov/pubmed/19651243

 

Zhang Y, Zhang L, Tan NZ, Qi Y, Gao L, Zhu JS FASEB J. March 2008 22 (Meeting Abstract Supplement) 1136.2. http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/1136.2

 

Thyagarajan A, Zhu J, Sliva D. International Journal of Oncology. 2007 Apr;30(4):963-9. http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_30_4_963

 

Chen W, Zhang Y, Tan NZ, Qi Y, Zhu JS. FASEB J. Meeting Abstracts, 2007, 21(6): Abstract# 852.3. http://www.fasebj.org/cgi/content/meeting_abstract/21/6/A1100-a

 

Sliva, D, and Thyagararjan, A., Acta Pharmacologica Sinica [Abstracts of the 15th World Congress of Pharmacology, July 2-7, 2006, Beijing, China] 2006 July; Supplement 1:1-489. (pg. 338). http://www.blackwell-synergy.com/doi/abs/10.1111/j.1745-7254.2006.00453.x

 

Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D. International Journal of Molecular Medicine. 2006 Oct;18(4):657-64. http://www.spandidos-publications.com/ijmm/article.jsp?article_id=ijmm_18_4_657

 

Thyagarajan A, Jiang J, Stanley G, Sliva D.  FASEB J., 2006; 20(5):A1012, Abstract# 652.6. http://www.fasebj.org/cgi/content/meeting_abstract/20/5/A1012-c

 

Jiang J, Slivova V, Sliva D. International Journal of Oncology, 2006, 29(3), 695–703. http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_29_3_695

 

Stanley G, Harvey K, Slivova V, Jiang J, Sliva D. Biochem Biophys Res Commun. 2005 Apr 29;330(1):46-52.  http://www.ncbi.nlm.nih.gov/pubmed/15781230

 

Jiang J, Slivova V, Harvey V, Valachovicova T, and Sliva D. Nutrition and Cancer, 2004, 49(2), 209–216.http://www.ncbi.nlm.nih.gov/pubmed/15489214?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

Slivovas, V., Valachoviciva, T., Jiang, J., Sliva, D. Journal of Cancer Integrative Medicine, 2004; 2:1, pp. 25-30. http://pnpcsw.pnpco.com/cadmus/testvol.asp?journal=jcim&year=2004

 

Sliva, D., Sedlak, M., Slivova, V., Valachovicova, T., Lloyd, F., HO, NW. Journal of Alternative and Complementary Medicine, 2003; 9:4, pp. 491-497. http://www.ncbi.nlm.nih.gov/pubmed/14499024?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

Lu QYa, Jin YSb, Zhang Qa, Zhang Zc, Heber Da, Go VLa, Li FPd, Rao JYb. Cancer Letters. 2004;216 (1):9-20. http://www.ncbi.nlm.nih.gov/pubmed/15500944?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

Lin, W.C., Wu, Y.W., Xie, M.C., Zhu, J.S., FASEB J. 2004; 18(4): A999 (Abstract #650.7). http://www.px2.com.tw/poster/No6.ReishiMax%20liver%20poster%20EB04.pdf

 

Jiang, J., Slivova, V., Valachovicova, T., Harvey, K., Sliva, D. International Journal of Oncology, 2004, 24: 1093-1099. http://www.spandidos-publications.com/ijo/24/5/1093

 

Zhao, C., Zhang, Y., Yin, W., Zhang, D., Guo, F., Zhu, JS. FASEB J., 17: A1099, 2003, Abstract# 689.4. http://www.px2.com.tw/poster/No5.ReishiMax%20FASEB%20poster.pdf

 

Wang YY, Wong CH, et al. Bioorganic & Medicinal Chemistry 2002;10:1057-1062. http://www.ncbi.nlm.nih.gov/pubmed/11836115?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

Ma J, Ye Q, Hua Y, Zhang D, Cooper R, Chang MN, Chang JY, Sun HH. New lanostanoids from the mushroom Ganoderma lucidum. Journal of Natural Product, 2002 Jan;65(1):72-5. http://pubs.acs.org/cgi-bin/abstract.cgi/jnprdf/2002/65/i01/abs/np010385e.html

 

Li C, Li Y, Sun HH. New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum. Nat Prod Res. 2006 Sep;20(11):985-91. http://www.ncbi.nlm.nih.gov/pubmed/17050181

 

Li C, Yin J, Guo F, Zhang D, Sun HH: Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum. Nat Prod Res. 2005 July; 19(5), 461–465. http://www.ncbi.nlm.nih.gov/pubmed/15938193

 

Tan N-Z, Chiang B-L, Thyagarajan A, Sliva D, Zhao C-S, Zhang Y, Zhu J-S. Proceedings of The 2011 International Meeting on Ganoderma Research. Aug. 17, 2011 Beijing. pp 44-46. Link

 

Yang JY, Zhang Y, Zhao C-S, Tan N-Z, Zhu J-S. Anti-oxidation and lifespan-extension activities of ReishiMax in oxidative stress and aging models. Proceedings of The 2011 International Meeting on Ganoderma Research. Aug. 17, 2011 Beijing. pp 47-49. https://www.researchgate.net/publication/280581216_Anti-oxidation_and_lifespan-extension_activities_of_ReishiMax_in_oxidative_stress_and_aging_models

 

Tan NZ, Li CL, Thyagarajan A, Sliva D, Zhang Y, Gao L, Zhu J-S. Proceedings of 2008 Symposium of Chin Asso Med Mycol. Oct 7-9, 2008 Nanchang, Jiangxi. Chinese Association of Medicinal Mycology Publishing, pp 165-171. Link

 

Lifepak

Lifepak is a comprehensive dietary supplement with important antioxidants, vitamins, minerals, and phytonutrients to support anti-aging benefits

 

Spitale RC, Cheng MY, Chun KA, Gorell ES, Munoz CA, Kern DG, Wood SM, Knaggs HE, Wulff J, Beebe KD, Chang AL. Differential effects of dietary supplements on metabolomic profile of smokers versus nonsmokers. Genome Med. 2012 Feb 23;4(2):14. doi: 10.1186/gm313. PubMed PMID: 22360970; PubMed Central PMCID: PMC3392760. http://www.ncbi.nlm.nih.gov/pubmed/22360970

 

Duan L, Zhao L, Liang C, Lu J, Gao L, Li G, Zhu JS. Improvement of exercise metabolism and carotenoids antioxidant scores with CordyMax and LifePak in young Chinese elite athletes. FASEB J April 6, 2010 24:805.4 http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/805.4?sid=5612edc2-ca96-42b2-9849-924abbea8f00

 

Duan L, Lu J, Li G, Zhu JS. Improvement of Skin Carotenoids Antioxidant Scores with G3 Drink and LifePak is affected by Endurance Training Intensity in Young Athletes. FASEB J. 2009 23:1007.3. http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/1007.3?maxtoshow=&hits=10&RESULTFORMAT=&andorexacttitle=and&andorexacttitleabs=and&fulltext=pharmanex&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

 

Bi SX, Li CL, Guo HW, Poole SL, Zhu JS. The effects of life styles and LifePak on human skin carotenoids scores measured by resonance Raman spectroscopy BioPhotonic Scanner. FASEB Journal 2007;21(4):A709. http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A709?maxtoshow=&hits=10&RESULTFORMAT=&author1=Bi&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=21&fdate=7/1/2006&tdate=6/30/2008&resourcetype=HWCIT

 

Guo HW, Li H, Huang ZY, Xue K, Zhou X, Ma YY, Liu M, Zhu ZG, Li CL, Zhu JS. Examination of Carotenoids in Human Skin by Biophotonic Raman Spectroscopy Scanner. J Environmental Occupat Med 23(3): 204-206, 2006. [No online abstract available]

 

Li CL, Bi SX, Poole S, Smidt C, Zhu JS. Human Skin Carotenoids in 88,611 subjects measured by Biophotonic Scanner. Chinese Journal of Clinical Pharmacy 2006;15(2):124-125. [No online abstract available]

 

Li CL, Guo HW, Bi SX, Zhu ZG, Zhu JS. Skin Carotenoids Measured by Resonance Raman Spectroscopy BioPhotonic Scanner and the Effects of Life Styles and LifePak on Human Carotenoids Nutritional Status and Skin Scores. Asian Pacific Journal of Clinical Nutrition 2006;15(Suppl.):S79. http://apjcn.nhri.org.tw/server/APJCN/Volume15/vol15apcns/IUNS-APCNS2006_HEC.pdf

 

Smidt CR, Mastaloudis A, Poole SL. A Double Blind Placebo Study Showing the Effect of LifePak Nano Supplementation on Skin Carotenoid Scores. Pharmanex In-house Study. February 2006. [No online abstract available]

 

Zukley LM, Nguyen V, Lowndes J, Smidt CR, Angelopoulos TJ, Rippe JM; Effects of Antioxidant Supplementation on Skin and Serum Antioxidants; FASEB J. 2006;20:A145. http://www.fasebj.org/cgi/content/meeting_abstract/20/4/A145a?maxtoshow=&hits=10&RESULTFORMAT=&author1=zukley&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=20&fdate=7/1/2005&tdate=6/30/2008&resourcetype=HWCIT

 

Smidt, C.R., Clinical Screening Study: Use of the Pharmanex BioPhotonic Scanner to assess skin carotenoids as a marker of antioxidant status. Pharmanex In-house Study. 2003. [No online abstract available]

 

Smidt C.R. and Shieh D. Non-invasive biophotonic assessment of skin carotenoids as a biomarker of human antioxidant status. FASEB J 2003, 17 (5): A1115. [No online abstract available]

 

Smidt CR, Ph.D., FACN, Effect of LifePak® Supplementation on Antioxidant Status Using BioPhotonic Raman Spectroscopy. Pharmanex In-house Study, 2002. [No online abstract available]

 

Smidt CR, Seidehamel RJ, Devaraj S, Jialal I, The Effects of a Nutritionally Complete Dietary Supplement (LifePak®) on Antioxidant Status and LDL-Oxidation in Healthy Non-Smokers. FASEB Journal 1999, Vol. 13, Issue 4, p. A546 (Abstract). [No online abstract available]

 

Smidt CR, Woehler DL, Seidehamel RJ, Devaraj S, Jialal I. Double-Blind, Placebo-Controlled Study of the Effects of LifePak® Supplementation on Antioxidant Status, Free Radical Activity and Resistance to LDLOxidation. Interior Design Nutritionals In-house Study, 1998. [No online abstract available]

 

Studies Utilizing the Pharmanex Biophotonic Scanner

Abstracts

 

1. Bi, S.X., Li, C.L., Guo, H.W., Poole, S., Zhu, J. S. The effects of life styles and LifePak on human skin carotenoids scores measured by resonance Raman spectroscopy BioPhotonic Scanner. FASEB Journal 2007;21(4):A709.  http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A709

 

2. Changling Li, Hongwei Guo, Senxu Bi, Zhu, Z.G., Zhu, J. S. Skin Carotenoids Measured by Resonance Raman Spectroscopy BioPhotonic Scanner and the Effects of Life Styles and LifePak on Human Carotenoids Nutritional Status and Skin Scores.  Asian Pacific Journal of Clinical Nutrition 2006;15(Suppl.):S79. [no online abstract available]

 

3. Zukley, LM., Nguyen,V, Lowndes, J., Smidt, C., Angelopoulos, TJ., Rippe, JM., Effects of antioxidant supplementation on skin and serum carotenoids, FASEB Journal 2006;20:A145.  http://www.fasebj.org/cgi/content/meeting_abstract/20/4/A145-a

 

4. Fiutem J, Zukley L, Geise T, Legowski P, Nguyen V, Dube T, Yount B, Smidt C, Angelopoulos T, Rippe J. Adiposity Negatively Influences Carotenoids and Antioxidant Status in Overweight Individuals. Medicine and Science in Sports and Exercise Suppl 2004;36(5):A302. [no online abstract available]

 

5. Smidt, C. R.; W. R. Gellermann and J. R. Zidichouski. Noninvasive Raman spectroscopy measurement of human carotenoid status. FASEB Journal 2004;18(4):A480. [no online abstract available]

 

6. Smidt, C.R., Shieh, D. Non-invasive, biophotonic assessment of skin carotenoids as a biomarker of human antioxidant status. FASEB Journal 2003;17(5):A1115. [no online abstract available]

 

7. Zukley L, Legowski P, Nguyen V, Geise T, Lowndes J, Melanson K, Angelopoulos T, Rippe J. The Effect of Weight Loss on Dietary Carotenoid and Skin Carotenoid Levels in Subjects Participating in a Weight Loss Study. Obesity Research Suppl 2004;12:A57. [no online abstract available]

 

Full-Length Articles Using Biophotonic Scanner Published in Peer Reviewed Journals

 

1. Aguilar SS, Wengreen HJ, Lefevre M, Madden GJ, Gast J. Skin carotenoids: a biomarker of fruit and vegetable intake in children. J Acad Nutr Diet. 2014 Aug;114(8):1174-80. http://www.ncbi.nlm.nih.gov/pubmed/24951435

 

2. Bergeson SD, Peatross JB, Eyring NJ, Fralick JF, Stevenson DN, Ferguson SB. Resonance Raman measurements of carotenoids using light-emitting diodes. Journal of Biomedical Optics. 2008;13(4):044026; http://arxiv.org/pdf/0801.1697v1.pdf

 

3. Guo HW, Li H, Huang ZY, Xue K, Zhou X, Ma YY, Liu M, Zhu ZG, Li CL, Zhu JS. Examination of Carotenoids in Human Skin by Biophotonic Raman Spectroscopy Scanner. Journal of Environmental and Occupational Medicine 2006;23(3):204-206.

 

4. Harpenau LA, Cheema AT, Zingale JA, Chambers DW, Lundergan WP. Effects of nutritional supplementation on periodontal parameters, carotenoid antioxidant levels, and serum C-reactive protein. J Calif Dent Assoc. 2011 May;39(5):309-12, 314-8. http://www.ncbi.nlm.nih.gov/pubmed/21721475

 

5. Henriksen BS, Chan G, Hoffman RO, Sharifzadeh M, Ermakov IV, Gellermann W, Bernstein PS. Interrelationships between maternal carotenoid status and newborn infant macular pigment optical density and carotenoid status. Invest Ophthalmol Vis Sci. 2013 Aug 15;54(8):5568-78.

 

6. Li CL, Bi SX, Poole S, Smidt C, Zhu JS.  Human Skin Carotenoids in 88,611 subjects measured by Biophotonic Scanner. Chinese Journal of Clinical Pharmacy 2006;15(2):124-125. [no online abstract available

 

7. Li CL, Bi SX, Zhu JS, Zhu ZG. New functions of carotenoids and clinical assessments. Shanghai Journal of Preventive Medicine 2006;6:261-264. [no online abstract available]

 

8. Rerksuppaphol S, Rerksuppaphol L. Effect of fruit and vegetable intake on skin carotenoid detected by non-invasive Raman spectroscopy. J Med Assoc Thai 2006;89(8):1206-12. http://www.mat.or.th/journal/readpdf.php?link=files/Vol89_No8_1206.pdf

 

9. Smidt, C.R. Non-invasive Raman spectroscopic detection of carotenoids in human skin as a biomarker of antioxidant status. J. Korean Acad Fam Med 2005;26(4):S398-408. [no online abstract available]

 

10. Smidt, C.R., Burke, D.S. Nutritional significance and measurement of carotenoids. Current Topics in Nutraceutical Research 2004;2(2):79-91. http://ctnr.newcenturyhealthpublishers.com/about/issue_2_2.php#2

 

11. Zidichouski, J.A.; Mastaloudis, A.; Poole, S.J.; Reading, J.C.; Smidt, C.R. Clinical validation of a non-invasive, Raman spectroscopic method to assess carotenoid nutritional status in humans. Journal of the American College of Nutrition. 2009;28(6):687-693. http://www.ncbi.nlm.nih.gov/pubmed/20516269

 

12. Holt EW, Wei EK, Bennett N, Zhang LM. Low skin carotenoid concentration measured by resonance Raman spectroscopy is associated with metabolic syndrome in adults. Nutr Res. 2014 Sep 6. pii: S0271-5317(14)00168-7. doi: 10.1016/j.nutres.2014.08.017. [Epub ahead of print] PubMed PMID: 25249018. http://www.ncbi.nlm.nih.gov/pubmed/25249018

 

13. Ramírez-Vélez R, González-Ruiz K, García S, López-Alban CA, Escudero N, Agredo-Zúñiga RA. Non-invasive assessment of β-carotene levels in the skin of colombian adults. Endocrinol Nutr. 2012 Apr 13. http://www.ncbi.nlm.nih.gov/pubmed/22503818

 

14. Richer SP, Stiles W, Graham-Hoffman K, Levin M, Ruskin D, Wrobel J, Park DW, Thomas C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: The Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. Optometry. Nov 2011; 82(11) 667-680. http://www.ncbi.nlm.nih.gov/pubmed/22027699

 

15. Lima XT, Kimball AB. Skin carotenoid levels in adult patients with psoriasis. J Eur Acad Dermatol Venereol. 2011 Aug;25(8):945-9. http://www.ncbi.nlm.nih.gov/pubmed/21054574

 

16. Rerksuppaphol S, Rerksuppaphol L. Carotenoid intake and asthma prevalence in Thai children. Pediatr Rep. 2012 Jan 2;4(1):e12. Full-length article available free of charge at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357611/pdf/pr-2012-1-e12.pdf

 

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

 

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